School Inner-City Asthma Intervention Study (SICAS-2)
SICAS-2 is the interventional phase of the School Inner-City Asthma Study (SICAS 1), an NIH-funded, prospective study evaluating school and classroom specific environmental risk factors and asthma morbidity in the Northeast. SICAS-2 is a randomized intervention trial to evaluate the effectiveness of two environmental interventions, one classroom-based (High Frequency Particulate Air (HEPA) filter) and the other school wide (Integrated Pest Management), to reduce asthma allergens.
There are four arms to the study: IPM School/Classroom Air Filter; IPM School/Classroom Sham (Placebo) Air Filter; Control School/Classroom Air Filter; Control School/Classroom Sham (Placebo) Air Filter
The study is recruiting elementary students (ages 4-15) with asthma from multiple classrooms in 40 Northeastern inner-city elementary schools. Children are extensively assessed prior to the intervention/school year and then followed up at 2, 4, 6, 8, and 10 months after school starts
The study collects detailed physiological, biological, patient-reported and environmental information, much of which is unique compared to the other 2 trials
This provides us with the unique opportunity to explore the association of PROMIS measures with biomarkers and physiological indicators of disease activity
As with the CHICAGO Plan, both English and Spanish-speaking participants will be enrolled